Abstract

Knockdown of miR-124 completely reverses the phenotypes observed in EPAC-/- mice, whereas over-expression of miR-124 mimics EPAC null mutation. [...] miR-124 constitutes a critical epigenetic signaling downstream of EPAC proteins for regulation of learning and social interactions.

Details

Title
EPAC null mutation impairs learning and social interactions via aberrant regulation of miR-124 and Zif268 translation
Author
Yang, Ying; Shu, Xiaogang; Liu, Dan; Pei, Lei; Zhu, Lingqiang; Tian, Qing; Wang, Jianzhi; Lu, Youming
First page
O12
Publication year
2012
Publication date
2012
Publisher
BioMed Central
e-ISSN
17501326
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/1750-1326-7-S1-O12
ProQuest document ID
920092153
Copyright
© 2012 Yang et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.