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Abstract
If poly(lactic acid) (PLA) nanoparticles carrying HIV proteins have shown to induce a high systemic humoral immune response in mice, rabbit or macaque following sub-cutaneous administration, cellular and mucosal responses are still faint. [...] to increase potency and specificity of mucosal immune responses, additional immunostimulatory signals, such as TLR ligands could be delivered with HIV antigens.
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