Abstract

Abstract: Regulatory DNA elements such as enhancers, silencers and insulators are embedded in metazoan genomes, and they control gene expression during development. Although they fulfil different roles, they share specific properties. Herein we discuss some examples and a parsimonious model for their function is proposed. All are transcription units that tether their target promoters close to, or distant from, transcriptional hot spots (or 'factories').

Details

Title
Enhancers and silencers: an integrated and simple model for their function
Author
Kolovos, Petros; Knoch, Tobias A; Grosveld, Frank G; Cook, Peter R; Papantonis, Argyris
First page
1
Publication year
2012
Publication date
2012
Publisher
BioMed Central
e-ISSN
17568935
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/1756-8935-5-1
ProQuest document ID
921749833
Copyright
© 2012 Kolovos et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.