Abstract

The microenvironment that metastatic cells engage and take advantage of to form a niche is a significant contributor to metastatic outgrowth. [...] the niche may possibly also contribute to cancer stem cell resistance to therapeutic intervention.

Details

Title
What does the concept of the stem cell niche really mean today?
Author
Lander, Arthur D; Kimble, Judith; Clevers, Hans; Fuchs, Elaine; Montarras, Didier; Buckingham, Margaret; Calof, Anne L; Trumpp, Andreas; Oskarsson, Thordur
Pages
19
Publication year
2012
Publication date
2012
Publisher
BioMed Central
e-ISSN
17417007
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
926926603
Copyright
© 2012 Lander et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.