Abstract

Doc number: 20

Abstract: The concurrence of multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS) is exceedingly rare and the pathological features have not been examined extensively. Here we describe the key pathological features of a 40 year old man with pathologically confirmed concurrent MS and ALS.

This is the most pathologically illustrative case of coincident MS and ALS demonstrating inflammatory and neurodegenerative features characteristic of each disease, and is the first to exhibit the presence of TDP-43 inclusions in this clinical entity. The intricate relationship between neuroinflammation and neurodegeneration in these diseases is discussed.

Details

Title
Concurrent multiple sclerosis and amyotrophic lateral sclerosis: where inflammation and neurodegeneration meet?
Author
Li, Grace; Esiri, Margaret M; Ansorge, Olaf; DeLuca, Gabriele C
Pages
20
Publication year
2012
Publication date
2012
Publisher
BioMed Central
e-ISSN
1742-2094
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/1742-2094-9-20
ProQuest document ID
929146350
Copyright
© 2012 Li et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.