Abstract

Objective: This study tried to evaluate whether a methacholine test may be influenced by the seasons. Methods: We considered 4826 consecutive subjects with normal spirometry (50.53% males; age: 35.1+-16.2; forced expiratory volume in one second: 99.5+-13.0%) who underwent a methacholine test for suspected asthma symptoms between 2000 and 2010. They were subdivided into four groups, like the seasons, according to the test dates. Results: A total of 1981 (41%) resulted normal (no PD 20 was obtained with 2400 μg of methacholine); the others showed a mean LogPD 20 of 2.52+-0.5 μg. The number of subjects with bronchial hyper-responsiveness (BHR) found in autumn (789, 62.3%) was higher than in summer (583, 56.7%; P=0.03). A higher number of females and overweight/obese subjects showed a BHR in autumn compared with the other seasons. The spring mean LogPD 20 value (2.48+-0.48 μg) was lower if compared with the one measured in summer (2.59+-0.49 μg; P=0.05). LogPD 20 value was lower in females and non-smokers in spring compared with summer (P<0.05). Overweight/obese non-smokers showed a lower LogPD 20 in spring and autumn compared with that in summer (P<0.05). Autumn was a risk factor (OR: 1.378; P=0.001) for BHR (using a PD 20 <2 400 μg as BHR limit), while spring (OR: 1.330; P=0.021) and autumn (OR: 1.331; P=0.020) were risk factors for a more severe BHR (using a PD 20 <400 μg as BHR limit). Conclusion: There was a higher probability of finding BHR in outpatients with suspected asthma in autumn and spring compared with summer. Spring is the season where BHR may be more severe. Females and overweight/obese subjects were those mainly involved in this seasonal variability of BHR.

Details

Title
Seasons can influence the results of the methacholine challenge test
Author
Sposato, Bruno; Scalese, Marco; Pammolli, Andrea; Scala, Raffaele; Naldi, Mario
Pages
61-68
Publication year
2012
Publication date
Apr 2012
Publisher
Medknow Publications & Media Pvt. Ltd.
ISSN
18171737
e-ISSN
19983557
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
996601033
Copyright
Copyright Medknow Publications & Media Pvt Ltd Apr 2012