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Abstract
Более 90 % мышиных зигот, у которых микрохирургически удалили треть цитоплазмы, развились в культуре до морфологически нормальных морул и бластоцист. Наблюдалось значительное замедление скоростей дробления и морфогенеза оперированных зародышей по сравнению с контрольными. Оперированные зародыши начинали образование бластоцели при меньшем числе клеток, чем контрольные, что соответствует гипотезе о влиянии ядерно-цитоплазматического соотношения на запуск кавитации. Сравнение преимплантационных эмбрионов, развивающихся в различных условиях (
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