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The mutation Gly99lys (E99K) in the cardiac actin (ACTC) gene has been found to cause hypertrophic cardiomyopathy (HCM) in 75 hypertrophic obstructive cardiomyopathy (HOCM) or LVNC patients. Transgenic mice expressing 50% E99K mutant cardiac actin in their hearts were generated and studied. Over 30% male and 70% female E99K mice died between 28 and 45 days. Anaesthetised 7-month-old male transgenic mice and...
