Content area
Abstract
The enzyme 5-lipoxygenase (5-LOX) initiates the biosynthesis of leukotrienes (LT), potent mediators of the inflammatory response. The first crystal structures of two complexes of inhibitor bound to 5-LOX reveal the functional consequences of the binding, including a change in the regiospecificity toward a 12/15-lipoxygenating enzyme.
Details
Title
5-LOX inhibition by natural products
Author
Rubbo Homero 1
; Wood, Irene 1
1 Departamento de Bioquímica, Facultad de Medicina, Universidad de la República and Centro de Investigaciones Biomédicas (CEINBIO), Montevideo, Uruguay (GRID:grid.11630.35) (ISNI:0000000121657640)
; Wood, Irene 1 1 Departamento de Bioquímica, Facultad de Medicina, Universidad de la República and Centro de Investigaciones Biomédicas (CEINBIO), Montevideo, Uruguay (GRID:grid.11630.35) (ISNI:0000000121657640)
Pages
714-715
Publication year
2020
Publication date
Jul 2020
ISSN
15524450
e-ISSN
15524469
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2415569462
Copyright
© Springer Nature America, Inc. 2020.