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Pediatr Nephrol (2016) 31:12011215 DOI 10.1007/s00467-016-3391-8
ABSTRACTS
Abstracts of the 2nd International Symposium on AKI in Children, June 2426, 2016, Cincinnati, Ohio, USA
Published online: 9 May 2016 # IPNA 2016
Acute Kidney Injury and Quality of Life in Children
Richardson K, Watson RS, Hingorani S
Seattle Childrens Hospital
Background: Acute kidney injury (AKI) occurs in 1050 % of hospitalized children. Little is known about the impact of AKI on long term quality of life. PedsQL is a validated scale to measure health related quality of life (HRQoL) in children.
Objective: To describe HRQoL in children following hospitalization associated AKI. We hypothesized that following severe AKI, children will have lower HRQoL than those with mild AKI or healthy controls.
Methods: This retrospective cohort study included children (118 years old) admitted to a large, academic medical center (March 2012February 2015) with AKI. Our historical control group (n = 1112) included children 018 years old admitted to medical/surgical services (not intensive care) between October 2011 and December 2013. All patients were enrolled in our centers Outcomes Assessment Program. This program collects Pediatric Quality of Life Inventory (PedsQL) 4.0 Generic Core Scale surveys on hospitalized children within 72 h of admission and within 8 weeks of discharge. Surveys are scored on 0 100 scale, with higher scores indicating better HRQoL. The mean score for healthy children in the community is 82. Previously established minimal clinically important difference on this scale is 4 points. KDIGO AKI criteria were used. Baseline creatinine was estimated using bedside Schwartz equation when no baseline available. We compared mean PedsQL scores in
AKI stage 2 & 3 combined (severe AKI) to AKI stage
1 (mild AKI) and to historical controls using two sample t-tests.
Results: We studied 139 children with AKI. AKI groups were similar in age, gender, ICU admission and surgical procedures. Mild and severe AKI groups had similar admission scores (50.6 v. 53.0, p = 0.71). Those with severe AKI tended toward lower follow up scores compared to those with mild AKI (85.8 v. 78.9, p = 0.11). Severe AKI patients had significantly lower admission scores (64.1 v. 53.0, p = 0.04) and follow up scores (86.5 v. 78.9, p = 0.01) than historical controls.
PedsQL Admission and Follow-up Scores by GroupSevere...