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Exp Brain Res (2014) 232:27092719 DOI 10.1007/s00221-014-3948-3
RESEARCH ARTICLE
Acute overthecounter pharmacological intervention does not adversely affect behavioral outcome following diffuse traumatic brain injury in the mouse
Jordan L. Harrison Rachel K. Rowe
Bruce F. OHara P. David Adelson Jonathan Lifshitz
Abstract Following mild traumatic brain injury (TBI), patients may self-treat symptoms of concussion, including post-traumatic headache, taking over-the-counter (OTC) analgesics. Administering one dose of OTC analgesics immediately following experimental brain injury mimics the at-home treated population of concussed patients and may accelerate the understanding of the relationship between brain injury and OTC pharmacological intervention. In the current study, we investigate the effect of acute administration of OTC analgesics on neurological function and cortical cytokine levels after experimental diffuse TBI in the mouse. Adult, male C57BL/6 mice were injured using a midline uid percussion (mFPI) injury model of concussion (610 min righting reex time for brain-injured mice). Experimental groups included mFPI paired with either ibuprofen (60 mg/kg, i.p.; n = 16), acetami
nophen (40 mg/kg, i.p.; n = 9), or vehicle (15 % ethanol
(v/v) in 0.9 % saline; n = 13) and sham injury paired OTC
Jordan L. Harrison and Rachel K. Rowe contributed equally to the design, execution, and interpretation of the study.
J. L. Harrison (*) R. K. Rowe P. D. Adelson J. Lifshitz BARROW Neurological Institute at Phoenix Childrens Hospital, Phoenix, AZ 85016, USAe-mail: [email protected]
J. Lifshitze-mail: [email protected]
J. L. Harrison R. K. Rowe P. D. Adelson J. Lifshitz Department of Child Health, University of Arizona College of Medicine-Phoenix, Phoenix, AZ, USA
J. L. Harrison P. D. Adelson J. Lifshitz
Interdisciplinary Graduate Program in Neuroscience, Arizona State University, Tempe, AZ,
USA
R. K. Rowe
Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, Lexington, KY, USA
R. K. Rowe B. F. OHara
Spinal Cord and Brain Injury Research Center (SCoBIRC), University of Kentucky College of Medicine, Lexington, KY, USA
B. F. OHara
Department of Biology, University of Kentucky College of Arts and Sciences, Lexington, KY, USA
J. Lifshitz
Phoenix Veteran Affairs Healthcare System, Phoenix, AZ, USA
Received: 30 October 2013 / Accepted: 3 April 2014 / Published online: 24 April 2014 Springer-Verlag Berlin Heidelberg 2014
medicine or vehicle (n = 710 per group). At 24 h after
injury, functional...