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Clinic Rev Allerg Immunol (2014) 47:354365
DOI 10.1007/s12016-014-8447-6
Alternaria alternata and Its Allergens: a Comprehensive Review
Irena Kustrzeba-Wjcicka & Emilia Siwak &
Grzegorz Terlecki & Anna Wolaczyk-Mdrala &
Wojciech Mdrala
Published online: 10 September 2014# Springer Science+Business Media New York 2014
Abstract Alternaria alternata is mainly an outdoor fungus whose spores disseminate in warm, dry air, so in temperate climates, their count peaks in the summers. Alternaria may also be found in damp, insufficiently ventilated houses, where its allergenic properties cocreate the sick building syndrome. Mold-induced respiratory allergies and research on Alternaria both have a lengthy history: the first was described as early as 1698 and the second dates back to 1817. However, the two were only linked in 1930 when Alternaria spores were found to cause allergic asthma. The allergenic extracts from Alternaria hyphae and spores still remain in use but are variable and insufficiently standardized as they are often a random mixture of allergenic ingredients and coincidental impurities. In contrast, contemporary biochemistry and molecular biology make it possible to obtain pure allergen molecules. To date, 16 allergens of A. alternata have been isolated, many of which are enzymes: Alt a 4 (disulfide isomerase), Alt a 6 (enolase), Alt a 8 (mannitol dehydrogenase), Alt a 10 (alcohol dehydrogenase), Alt a 13 (glutathione-S-transferase), and Alt a MnSOD (Mn superoxide dismutase). Others have structural and regulatory functions: Alt a 5 and Alt a 12 comprise the structure of large ribosomal subunits and mediate translation, Alt a 3 is a molecular chaperone, Alt a 7 regulates transcription, Alt a NTF2 facilitates protein import into the nucleus, and Alt a TCTP acts like a cytokine. The function of four allergenic proteins, Alt a 1, Alt a 2, Alt a 9, and Alt a 70 kDa, remains unknown.
Keywords Alternaria alternata . Allergenicity . Fungal allergens . IgE . Recombinant allergens . Sensitizing proteins
Introduction
Alternaria alternata, the more common species of genus Alternaria, is a fungus whose spores occur worldwide in two main environments. Throughout the year, the spores can be found in the organic constituents of soil. From spring to autumn, they become airborne and are therefore even more ubiquitous. Though usually considered saprophytic contaminants, Alternaria is now held to be responsible for a number of disorders....