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Abstract
The reaction kinetics of succinic anhydride with amine-containing drugs benzocaine, procaine and sulfanilamide was studied. It is shown that the reaction in the initial period is autocatalytic; subsequently the amidation process is dominant, which corresponds to second order reaction type. The dependence of the reaction kinetic parameters on the properties of the medium and the structure of the amine is analyzed. Equations are given that link the value of the amidation rate constant with the characteristics of organic solvents: polarity, basicity, donor and acceptor properties.
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Details
1 Donetsk National University, Department of Chemistry, 24 University St., 83001, Donetsk; L. M. Litvinenko Institute of Physical–Organic and Coal Chemistry, 70 R. Luxembourg St., 83114, Donetsk
2 L. M. Litvinenko Institute of Physical–Organic and Coal Chemistry, 70 R. Luxembourg St., 83114, Donetsk
3 Donetsk National University, Department of Chemistry, 24 University St., 83001, Donetsk