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Cancer Causes Control (2009) 20:581590
DOI 10.1007/s10552-008-9266-y
ORIGINAL PAPER
Anthropometric factors in differentiated thyroid cancer in French Polynesia: a casecontrol study
Pauline Brindel Franoise Doyon Frdrique Rachdi Jean-Louis Boissin Joseph Sebbag Larrys Shan Vaiana Chungue Frdrique Bost-Bezeaud Patrice Petitdidier John Paoaafaite Joseph Teuri Florent de Vathaire
Received: 23 May 2008 / Accepted: 7 November 2008 / Published online: 30 November 2008 Springer Science+Business Media B.V. 2008
AbstractObjectives French Polynesia has one of the worlds highest thyroid cancer incidence rates. A casecontrol study among native residents of French Polynesia included 219 cases of differentiated thyroid cancers diagnosed between 1979 and 2004 (195 women/24 men) matched with 359 population controls (315 women/44 men) on the date of birth.
Methods Anthropometric factors were analyzed by conditional logistic regression.
Results The risk of thyroid cancer for women in the highest quartile of body mass index (BMI) before diagnosis and at age 18 was 2.3-fold higher (95% CI, 1.14.7 p = 0.04) and 2.3-fold higher (95% CI, 1.24.4 p \ 0.01), respectively, compared with the lowest. Women who were
overweight (BMI = 2529.9 kg/m2) or obese (BMI C 30 kg/m2) at age 18 and before diagnosis had an increased risk compared with those with a normal lifelong weight (OR = 6.2; 95% CI, 2.515.5 p \ 0.01). Results for excess weight appeared in similar directions for men, although the number of cases was too small to provide reliable estimates. Height was positively associated with thyroid cancer among men and women.
Conclusion This study shows the role of excess body weight, especially if the onset is during early adulthood, and elevated height in the risk of differentiated thyroid cancer in populations born in French Polynesia.
Keywords Body height Body mass index
Casecontrol studies Polynesia Thyroid neoplasms
P. Brindel F. Doyon V. Chungue F. de Vathaire (&)
INSERM Unit 605, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, Francee-mail: [email protected]
P. Brindel F. Doyon V. Chungue F. de Vathaire
Department of Biostatistics and Epidemiology, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France
P. Brindel F. Doyon V. Chungue F. de Vathaire
University Paris XI, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France
F. RachdiDepartment of Diabetology and Endocrinology, Territorial Hospital Mamao, BP 1640, 98713 Papeete, French Polynesia