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DOI 10.1007/s10517-015-3137-9
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Bulletin of Experimental Biology and Medicine, Vol. 160, No. 2, December, 2015 PHARMACOLOGY AND TOXICOLOGY
Antioxidant Effect of Polyoxidonium and Metaprot during Bronchopulmonary Inammation in Rats
I. V. Zarubina and P. D. Shabanov
Translated from Byulleten Eksperimentalnoi Biologii i Meditsiny, Vol. 160, No. 8, pp. 200-203, August, 2015 Original article submitted November 7, 2014
The antioxidant effects of individual or combined application of polyoxidonium and metaprot were examined in rats with acute bronchopulmonary inammation. By degree of antioxidant potency, polyoxidonium was inferior to metaprot, but their combined application produced more potent antioxidant effect. Polyoxidonium and metaprot in low concentrations increased and in high concentrations suppressed spontaneous biochemiluminescence in the model system of alveolar macrophages.
Key Words: bronchopulmonary inammation; polyoxidonium; metaprot; lipid peroxidation
Disturbances accompanying bronchopulmonary diseases are closely related to mechanisms of unspecic resistance and immunological defense, oxygen supply system, and metabolism [3]. In light of this, complex therapy of bronchopulmonary inammation should employ drugs with a broad prole of pharmacological activity that can correct disturbances in the energy metabolism, free radical processes, and immune system and stimulate the adaptive potencies in the organism. In most features, an antihypoxant metaprot and immunomodulator polyoxidonium (PO) meet these requirements.
Metaprote possesses the energy stabilizing and antioxidant properties, which are especially needed during hypoxia that develops in parallel with bronchopulmonary diseases [4,9]. PO activates the unspecic resistance of the organism and up-regulates the humoral and cellular immunity. An important feature of PO is its ability to stimulate the anti-infectious stability of the organism. PO affects all the elements of phagocytosis: it enhances the absorption capacity and bactericidal activity of the phagocytes, and augments clearance of alien particles from circulation. While participating in induction of synthesis of cytokines, PO plays the role of true immunomodulator by stimulating their spontaneous and inducible synthesis [6]. In
complex therapy of various diseases, PO is a reliable partner to antiviral, antibacterial, antifungal, and other pharmacological agents [5]. The combined application of metaprot with PO should enhance effectiveness of bronchopulmonary therapy. Regretfully, there are few data on the antioxidant properties of PO in pulmonary tissues and immunocompetent cells during broncho-pulmonary inammation.
Our aim was to examine the antioxidant properties of PO, metaprot, and their combination during bronchopulmonary inammation in rats.
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