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Web End = Neurol Sci (2016) 37:763767 DOI 10.1007/s10072-016-2494-0
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Web End = Antioxidativeoxidative balance in epilepsy patientson antiepileptic therapy: a prospective casecontrol study
Selda Keskin Guler1 Bilal Aytac2 Zahide Esra Durak3 Burcu Gokce Cokal1
Nalan Gunes1 Ilker Durak4 Tahir Yoldas1
Received: 14 September 2015 / Accepted: 21 January 2016 / Published online: 1 February 2016 Springer-Verlag Italia 2016
Abstract Oxidative stress has been implicated in various disorders, including epilepsy. The aim of this study was to investigate the oxidant and antioxidant status of patients with epilepsy using antiepileptic drugs regularly and to compare them with healthy subjects. We investigated serum catalase (CAT), malondialdehyde (MDA), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and xanthine oxidase (XO) levels in 58 epilepsy patients and 25 healthy controls. Patients were divided into polytherapy (n = 17) and monotherapy (n = 41) groups, and antioxidant status was compared between the two groups and controls. There was no signicant difference between the patient and control groups in terms of age or gender (p [ 0.05). The mean duration of illness in the patients was 14.8 years, and the mean duration of treatment was 11.4 years. Comparison of the patient and control groups in terms of oxidative stress and antioxidant defence parameters revealed signicantly higher MDA, GSH-Px, XO and lower level of CAT, SOD levels (p \ 0.05). There were no differences in CAT, MDA, GSH-Px or SOD levels
between the monotherapy and polytherapy groups; but the XO level was higher in the monotherapy group (p \ 0.05).
Although the XO level was decreased by polytherapy, it was higher than in controls. Our study found signicantly low level of antioxidants in patients with epilepsy as compared to control. Thus, antiepileptic treatment did not improve oxidative stress parameters. Furthermore, our results show that polytherapy does not change the situation as compared with monotherapy. Antioxidant replacement therapy may benet these patients.
Keywords Oxidative balance Antioxidant effect
Antiepileptic drugs Polytherapy Monotherapy
Introduction
Epilepsy is a fairly common chronic, complex neurological disease known since antiquity, and affects 13 % of the...