ARTIGOS
Avaliação da reação de mitsuda em pacientes virchovianos inativos antes e após imunoterapia
Maria Sueli Parreira de Arruda; Raul Negrão Fleury; Maria Esther Salles Nogueira; Somei Ura; Olavo Speranza de Arruda
Endereço para correspondência
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RESUMO
Neste estudo investigou-se o potencial imunomodulador do levamisole e da mistura BCG/Mycobacterium leprae em pacientes virchovianos inativos, utilizando como parâmetro a reação de Mitsuda. Vinte pacientes, classificados como Mitsuda histologicamente negativos há 10 anos, foram divididos em três grupos: cinco pacientes que foram somente reavaliados frente a mitsudina: oito pacientes que receberam levamisole e, sete que receberam a mistura de BCG vivo mais M. leprae morto. Os resultados mostraram que: 1) o levamisole não alterou a reatividade à mitsudina em nenhum dos casos estudados; 2) as modificações da reatividade verificadas com o uso da mistura (tres casos) ou aquelas que ocorreram espontaneamente (tres casos) foram sempre de pequena amplitude e refletiram variações próprias de pacientes com algum grau de resistência ao Mycobacterium leprae.
Palavras-chave: Hanseníase. Imunoterapia. Levamisole. BCG/Mycobacterium leprae.
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ABSTRACT
In this study the immunopotentiator levamisole as well as a mixture of BCGMycobacterium leprae were investigated in inactive lepromatous leprosy patients by using the Mitsuda reaction as a parameter. Twenty lepromatous patients ten years ago classified as histologically negative for Mitsuda's test were divided into three groups: five patients that were only retested with Mitsuda antigen; eight patients that received oral levamisol and seven patients that received a mixture of alive BCG plus autoclaved M. leprae.The results indicated that: 1) the levamisole did not alter the reactivity to lepromin in any of the patients studied) 2) neither the changes in the reactivity to lepromin by using the mixture (3 cases) nor those that occurred spontaneously (3 cases) were clear. They properly reflected the natural variation of patients with some degree of resistance to Mycobacterium leprae.
Keywords: Leprosy. Immunotherapy. Levamisole. BCG/Mycobacterium leprae.
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REFERÊNCIAS BIBLIOGRÁFICAS
1. Arora SK, Singh G, Sen PC. Effect of levamisole therapy on, lepromin reaction in leproniatous leprosy cases. International Journal of Leprosy 53:113-114,1985. [ Links ]
2. Arruda MSE Arruda OS, Fleury RN, Opromolla DVA, Ura S. Estudo da imunidade celular em pacientes branqueados. Medicina Cutanea Ibero Latina Americana 10:231-238,1982. [ Links ]
3. Bera 0K, Sen PC. Effect of levamisole on bacterial index in BL and LL leprosy. International Journal of Leprosy 53:198-200,1985. [ Links ]
4. Birdi TJ, Mistry NS, Mahadevan PR, Antia NS. In vitro studies on the effect of levamisole in lepromatous leprosy. Journal of clinical and laboratorial Immunology 13:93-96,1984. [ Links ]
5. Convit J, Aranzazu N, Ulrich M, Pinardi ME, Reyes O, Alvarado J. Immunotherapy with a mixture of Mycobacterium leprae and BCG in different forms of leprosy and Mitsuda negative contacts. International Journal of Leprosy 50:415-424, 1982. [ Links ]
6. Convit J, Aranzazu N, Ulrich M, Pinardi ME, Reyes O, Alvarado J. The development of vaccination model using two microorganism and its application in leprosy and leishmaniasis. Leprosy Review 57(supl. 2);263-273,1986. [ Links ]
7. Dharmendra MB. Levamisole in the treatment of ENL in leprosy. Indian Journal of Leprosy 47:1-10, 1985. [ Links ]
8. Kar HK, Bhatia VN, Zinod Kunar CHD, Siruban P, Roy RG. Evaluation of levamisole, an immunopotentiator in treatment of lepromatous leprosy. Indian Journal of Leprosy 58:592-600, 1986. [ Links ]
9. Kim WS, CinnYW. Therapeutic trial of levamisole in patients with leprosy. Scientia Leprologica 3:65-72,1980. [ Links ]
10. Las Aguas JT, Gatti CF, Herburger E. Modificaciones clinicas e histologicas de la reaccion de Mitsuda en enfermos de la lepra lepromatosa inactiva. Revista de leprologia - Fontilles 11:37-44,1977. [ Links ]
11. Mitsuda K. On the value of a skin reaction to a suspension of leprous nodules. International Journal of Leprosy 21:347-58,1953. [ Links ]
12. Ramu G, Segupta U. Preliminary trial of intervention. Levamisole terapy in persistently bacteriologically positive lepromatous leprosy. Leprosy in India 55:64-7,1983. [ Links ]
13. Reitan LJ, Beleheu A. Failure of levamisole to restore in vitro lymphocyte responsiveness in lepromatous leprosy patients. Leprosy Review 54:153-154,1983. [ Links ]
14. RotbergA. Valor prognóstico da lepromino-reação de Mitsuda. Observação de 445 casos durante 5 a 6 anos. Revista Brasileira de Leprologia 12:367- 377,1944. [ Links ]
15. Tawar GE Leprosy vaccine trials. International Journal of Leprosy 57:292-294,1989. [ Links ]
16. Young DB. Immunology. International Journal of Leprosy, 57:275-277,1989. [ Links ]
17. Waters MFR, Ridley DS, Lucas B. Positive Mitsuda lepromin reaction in long-term treated lepromatous leprosy. Leprosy Review 61:347- 352,1990. [ Links ]
Endereço para correspondência:
Profa. Maria Sueli Parreira Arruda.
Depto. de Ciências Biológicas, Faculdade de Ciências/UNESP.
Av. Engò Luiz Edmundo Coube s/n,
Vargem Limpa,
17033-360
Bauru, SE
Fax: (0142) 30 - 4470.
Recebido para publicação em 27/07/94.
Departamento de Ciências Biológicas da Faculdade de Ciências da Universidade Estadual Paulista e Instituto Lauro de Souza Lima, Bauru, SP, Brasil.
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Copyright Sociedade Brasileira de Medicina Tropical Jul/Sep 1995
Abstract
In this study the immunopotentiator levamisole as well as a mixture of BCGMycobacterium leprae were investigated in inactive lepromatous leprosy patients by using the Mitsuda reaction as a parameter. Twenty lepromatous patients ten years ago classified as histologically negative for Mitsuda's test were divided into three groups: five patients that were only retested with Mitsuda antigen; eight patients that received oral levamisol and seven patients that received a mixture of alive BCG plus autoclaved M. leprae.The results indicated that: 1) the levamisole did not alter the reactivity to lepromin in any of the patients studied) 2) neither the changes in the reactivity to lepromin by using the mixture (3 cases) nor those that occurred spontaneously (3 cases) were clear. They properly reflected the natural variation of patients with some degree of resistance to Mycobacterium leprae.
You have requested "on-the-fly" machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Show full disclaimer
Neither ProQuest nor its licensors make any representations or warranties with respect to the translations. The translations are automatically generated "AS IS" and "AS AVAILABLE" and are not retained in our systems. PROQUEST AND ITS LICENSORS SPECIFICALLY DISCLAIM ANY AND ALL EXPRESS OR IMPLIED WARRANTIES, INCLUDING WITHOUT LIMITATION, ANY WARRANTIES FOR AVAILABILITY, ACCURACY, TIMELINESS, COMPLETENESS, NON-INFRINGMENT, MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. Your use of the translations is subject to all use restrictions contained in your Electronic Products License Agreement and by using the translation functionality you agree to forgo any and all claims against ProQuest or its licensors for your use of the translation functionality and any output derived there from. Hide full disclaimer