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npg 201 5 Nature America, Inc. All rights reserved.
Note 2) is available as a user-friendly web interface (http://www.transvar.net
Web End =http://www.trans http://www.transvar.net
Web End =var.net ) or a downloadable version for batch analysis (Supplementary Software and https://bitbucket.org/wanding/transvar
Web End =https:// bitbucket.org/wanding/transvar ).
Note: Any Supplementary Information and Source Data files are available in the online version of the paper (http://www.nature.com/doifinder/10.1038/nmeth.3622
Web End =doi:10.1038/nmeth.3622 ).
ACKNOWLEDGMENTS
We thank P. Ng and K. Shaw for critical feedback, as well as A. Johnson, A. Bailey, V. Holla, B. Litzenburger, J. Zhang and A. Chang for assistance. This work was supported in part by the US National Institutes of Health (grants CA172652, CA168394, CA083639, CA143883, UL1 TR000371, P50 CA083639, U54 CA112970 and P50 CA098258), the MD Anderson Cancer Center Sheikh Khalifa Ben Zayed Al Nahyan Institute of Personalized Cancer Therapy, the Bosarge Family Foundation, the Mary K. Chapman Foundation, the Michael & Susan Dell Foundation (honoring Lorraine Dell) and the National Cancer Institute Cancer Center (Support Grant P30 CA016672).
AUTHOR CONTRIBUTIONS
K.C. conceived the project. T.C., W.Z. and K.C. designed the studies. W.Z. and T.C. developed the tool and performed the analysis. Z.C. prepared the databases. W.Z., T.C., M.A.R., J.M.M. and C.W. set up the web-application interface. J.Z. and F.M.-B. detected clinical actionable mutations and informed clinical impact. T.C., W.Z., J.N.W., G.B.M. and K.C. interpreted the results and wrote the manuscript.
COMPETING FINANCIAL INTERESTS
The authors declare no competing financial interests.
Wanding Zhou1,6, Tenghui Chen1,6, Zechen Chong1, Mary A Rohrdanz1, James M Melott1, Chris Wakefield1, Jia Zeng2, John N Weinstein1,3, Funda Meric-Bernstam2,4,5, Gordon B Mills2,3 & Ken Chen1
1Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. 2Khalifa Bin Zayed Al Nahyan Institute of Personalized Cancer Therapy, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. 3Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
4Department of Investigational Cancer Therapy, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. 5Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. 6These authors contributed equally to this work. e-mail: mailto:[email protected]
Web End [email protected]
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