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Abstract
Recommended supplementary drugs were beta-blockers and alpha-blockers, which have inferior effects on clinical outcomes.34 The results of the ACCOMPLISH trial may suggest that doses of thiazide-type diuretics that are equivalent to 25 mg or less of hydrochlorothiazide per day are less effective for the prevention of cardiovascular events than full doses of amlodipine or doses of diuretics used in previous trials.