Benidipine/diltiazem: Increased frequency of vasospastic angina attacks due to switch from brand-name drug to a generic drug: 2 case reports

A 70-year-old woman and a 50-year-old man developed an increased frequency of vasospastic angina attacks after switching from a brand-name benidipine or diltiazem [benidipine hydrochloride, diltiazem hydrochloride] to a generic benidipine or diltiazem, due to lower efficacy of generic benidipine or diltiazem [benidipine hydrochloride, diltiazem hydrochloride; routes not stated].

Case 1: A 70-year-old woman developed an increased frequency of vasospastic angina attacks after switching from a brand-name benidipine to a generic benidipine. She was diagnosed with vasospastic angina. Pitavastatin and diltiazem 100mg capsule two times a day were prescribed. Ten months later, isosorbide...