Abstract

Background

There is a worldwide demand for phenolic compounds (PC) because they exhibit several biological activities. The present investigation deals with a comprehensive study on the biological activities of phenolic compounds extracted from flaxseed meal (FM) with the aid of ultrasonic waves.

Results

The antioxidant activity of the PC extract of FM is considerably high when measuring it by the three methods (the β-carotene coupled oxidation method, the DPPH free radical scavenging activity method, and measuring the reducing antioxidant power). The toxicity test revealed that the PC extract was nontoxic on normal retina cell line. Also, it has no anticoagulating activity. Evaluation of antimicrobial activity showed that it is effective towards four strains only from seven. FM phenolic extract has been evaluated as chemo-preventive agents by testing the product for any cytotoxic activity against human tumor cell lines. The highest inhibitory effect was achieved on cell lines of colon carcinoma and lung carcinoma with IC50 = 22.3 and 22.6 μ/ml respectively.

Conclusion

The PC extracted from FM showed high antioxidant activity, nontoxic on normal retina cell line, no anticoagulating activities, and an antimicrobial effect on some pathogenic bacteria, so the phenolic compounds extracted from flaxseed meal showed significant biological activities.

Details

Title
Biological activities of phenolic compounds extracted from flaxseed meal
Author
Akl, Engy M 1   VIAFID ORCID Logo  ; Mohamed, Samira S 1 ; Hashem, Ahmed I 2 ; Taha, Fakhriya S 1 

1  National Research Centre, Fats and Oils Department, Cairo, Egypt (GRID:grid.419725.c) (ISNI:0000 0001 2151 8157) 
2  Ain Shams University, Chemistry Department, Faculty of Science, Cairo, Egypt (GRID:grid.7269.a) (ISNI:0000 0004 0621 1570) 
Publication year
2020
Publication date
Dec 2020
Publisher
Springer Nature B.V.
e-ISSN
2522-8307
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/s42269-020-0280-x
ProQuest document ID
2356447687
Copyright
Bulletin of the National Research Centre is a copyright of Springer, (2020). All Rights Reserved. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.