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METHOD OF PREPARATION
1. Calculate the required quantity of each ingredient for the total amount to be prepared.
2. Accurately weigh and/or measure each ingredient.
3. Dissolve the cocaine hydrochloride and the morphine sulfate in the purified water.
4. Add simple syrup to about 90 mL.
5. Add the desired flavor and mix well.
6. Add sufficient simple syrup to volume and mix well.
7. Package and label.
Note: The simple syrup and flavor can be replaced with a flavored syi~up.
PACKAGING
Package in tight, light-resistant containers.1
LABELING
Keep out of reach of children. Use only as directed. Store in a refrigerator.
STABILITY
A beyond-use date of 14 days when stored in a refrigerator would be appropriate for this preparation.1
USE
Brompton's Mixture (Brompton's Cocktail) has been used in the treatment of severe pain in patients with terminal cancer.
QUALITY CONTROL
Quality-control assessment can include weight/volume, pH, specific gravity, active drug assay, color, rheological properties/pourability, physical observation, and physical stability (discoloration, foreign materials, gas formation, mold growth).2
DISCUSSION
Brompton's Mixture (Brompton Hospital, England) has been used in the treatment of severe pain,...