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A 29-year-old woman developed delayed-onset anaphylaxis during treatment with bupropion.
The woman who had a medical history of depression was started on treatment with bupropion sustained-release 150mg daily for 1 week, and then the dosage was increased to 150mg twice daily [route not stated]. On day 21 of bupropion therapy, she presented to the emergency department (ED) with complaints of a diffuse rash with mild difficulty swallowing and chest tightness for a day. She had already taken 3 doses of diphenhydramine with no benefit. During examination, she was...