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METHOD OF PREPARATION
1. Calculate the required quantity of each ingredient for the total amount to be prepared.
2. Accurately weigh and/or measure each ingredient.
3. Dissolve the camphor, menthol and phenol in the alcohol.
4. Sprinkle the carbomer on the alcoholic solution slowly with stirring.
5. Add 60 mL of purified water and mix well.
6. Add sufficient trolamine to the desired viscosity or a pH of about 6.
7. Add sufficient purified water to volume and mix well.
8. Package and label.
PACKAGING
Package in tight, light-resistant containers.1
LABELING
Keep out of reach of children. Use only as directed. For external use only.
STABILITY
A beyond-use date of 6 months is appropriate for this preparation.1
USE
Camphor, menthol and phenol gel has been used for the topical treatment of minor skin irritations and itching.
QUALITY CONTROL
Quality-control assessment can include theoretical weight compared to actual weight, pH, specific gravity, active drug assay, color, clarity, texture-surface, texture-spatula spread, appearance, feel, rheological properties and physical observations.2
DISCUSSION
The rubefacient properties of camphor and menthol and the antiseptic properties of phenol combine to...