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In his article ( Med Humanit 2004;30 :32-5 ), H Davies asks whether Mary Shelley's novel, Frankenstein, can be read as an early research ethics text. 1 It is misguided to give the impression, as the author does at times, that Shelley was ghost-writing for a future institutional review board: there are reasons for believing that the novel's theme of overreaching was a largely unintended rebuke to the fame-seeking writers who made her early life such a heady but wary one: her dead mother Mary...