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© 2020 Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/ . Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Despite regulatory approval of several immune-based treatments for cancer in the past decade, a number of barriers remain to be addressed in order to fully harness the therapeutic potential of the immune system and provide benefits for patients with cancer. As part of the Cancer Moonshot initiative, the Immuno-Oncology Translational Network (IOTN) was established to accelerate the translation of basic discoveries to improve immunotherapy outcomes across the spectrum of adult cancers and to develop immune-based approaches that prevent cancers before they occur. The IOTN currently consists of 32 academic institutions in the USA. By leveraging cutting-edge preclinical research in immunotherapy and immunoprevention, open data and resource sharing, and fostering highly collaborative team science across the immuno-oncology ecosystem, the IOTN is designed to accelerate the generation of novel mechanism-driven immune-based cancer prevention and therapies, and the development of safe and effective personalized immuno-oncology approaches.

Details

Title
Cancer Moonshot Immuno-Oncology Translational Network (IOTN): accelerating the clinical translation of basic discoveries for improving immunotherapy and immunoprevention of cancer
Author
Annapragada, Ananth 1 ; Sikora, Andrew 2 ; Bollard, Catherine 3 ; Conejo-Garcia, Jose 4 ; Conrad Russell Cruz 3 ; Shadmehr Demehri 5 ; Demetriou, Michael 6 ; Demirdjian, Levon 7 ; Fong, Lawrence 8 ; Horowitz, Mary 9 ; Hutson, Alan 10 ; Kadash-Edmondson, Kathryn 7 ; Kufe, Donald 11 ; Lipkin, Steven 12 ; Liu, Song 10 ; McCarthy, Claire 13 ; Morgan, Martin 10 ; Morris, Zachary 14 ; Pan, Yang 7 ; Pasquini, Marcelo 9 ; Schoenberger, Stephen 15 ; Eliezer Van Allen 11 ; Vilar, Eduardo 16 ; Xing, Yi 7 ; Zha, Wenjuan 10 ; Odunsi, Adekunle 17 

 Singleton Department of Pediatric Radiology, Texas Children’s Hospital, Houston, Texas, USA 
 Bobby R. Alford Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, Texas, USA 
 Center for Cancer and Immunology Research, Children’s National Medical Center, Washington, District of Columbia, USA 
 Department of Immunology, H Lee Moffitt Cancer Center and Research Center, Tampa, Florida, USA 
 Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts, USA 
 Department of Neurology, University of California Irvine, Irvine, California, USA 
 Center for Computational and Genomic Medicine, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA 
 Department of Hematology and Oncology, University of California San Francisco, San Francisco, California, USA 
 Department of Medicine, Medical College of Wisconsin and Center for International Blood and Marrow Transplant Research, Milwaukee, Wisconsin, USA 
10  Department of Biostatistics and Bioinformatics, Roswell Park Cancer Institute, Buffalo, New York, USA 
11  Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA 
12  Department of Medicine, Weill Cornell Medicine, New York, New York, USA 
13  Division of Cancer Biology, National Cancer Institute, Rockville, Maryland, USA 
14  Department of Human Oncology, University of Wisconsin Madison School of Medicine and Public Health, Madison, Wisconsin, USA 
15  Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA 
16  Department of Clinical Cancer Prevention, University of Texas MD Anderson Cancer Center, Houston, Texas, USA 
17  Department of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, New York, USA 
First page
e000796
Section
Review
Publication year
2020
Publication date
Jun 2020
Publisher
BMJ Publishing Group LTD
e-ISSN
20511426
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2552982983
Copyright
© 2020 Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/ . Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.