Abstract

Doc number: 82

Abstract

Background: Cyclin-dependent kinase 5 (Cdk5), which is activated by binding to p35 or p39, is involved in synaptic plasticity and affects learning and memory formation. In Cdk5 knockout (KO) mice and p35 KO mice, brain development is severely impaired because neuronal migration is impaired and lamination is disrupted. To avoid these developmental confounders, we generated inducible CreER-p35 conditional (cKO) mice to study the role of Cdk5/p35 in higher brain function.

Results: CreER-p35 cKO mice exhibited spatial learning and memory impairments and reduced anxiety-like behavior. These phenotypes resulted from a decrease in the dendritic spine density of CA1 pyramidal neurons and defective long-term depression induction in the hippocampus.

Conclusions: Taken together, our findings reveal that Cdk5/p35 regulates spatial learning and memory, implicating Cdk5/p35 as a therapeutic target in neurological disorders.

Details

Title
Cdk5/p35 functions as a crucial regulator of spatial learning and memory
Author
Mishiba, Tomohide; Tanaka, Mika; Mita, Naoki; He, Xiaojuan; Sasamoto, Kodai; Itohara, Shigeyoshi; Ohshima, Toshio
Publication year
2014
Publication date
2014
Publisher
BioMed Central
e-ISSN
1756-6606
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/s13041-014-0082-x
ProQuest document ID
1626769415
Copyright
© 2014 Mishiba et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.