Content area
Full Text
http://crossmark.crossref.org/dialog/?doi=10.1007/s11060-015-1882-2&domain=pdf
Web End = http://crossmark.crossref.org/dialog/?doi=10.1007/s11060-015-1882-2&domain=pdf
Web End = http://crossmark.crossref.org/dialog/?doi=10.1007/s11060-015-1882-2&domain=pdf
Web End = http://crossmark.crossref.org/dialog/?doi=10.1007/s11060-015-1882-2&domain=pdf
Web End = http://crossmark.crossref.org/dialog/?doi=10.1007/s11060-015-1882-2&domain=pdf
Web End = J Neurooncol (2015) 125:157166 DOI 10.1007/s11060-015-1882-2
http://crossmark.crossref.org/dialog/?doi=10.1007/s11060-015-1882-2&domain=pdf
Web End = http://crossmark.crossref.org/dialog/?doi=10.1007/s11060-015-1882-2&domain=pdf
Web End = http://crossmark.crossref.org/dialog/?doi=10.1007/s11060-015-1882-2&domain=pdf
Web End = CLINICAL STUDY
http://crossmark.crossref.org/dialog/?doi=10.1007/s11060-015-1882-2&domain=pdf
Web End = http://crossmark.crossref.org/dialog/?doi=10.1007/s11060-015-1882-2&domain=pdf
Web End = Changes in functional MRI signals after 3D based radiotherapy of glioblastoma multiforme
rpd Kovcs1,3 Mikls Emri2 Gbor Opposits2 Tams Pisk2
Csaba Vandulek1 Csaba Glavk1 Zoltn Szalai1 Gergely Bir1
Gbor Bajzik1 Imre Repa1
Received: 17 October 2014 / Accepted: 8 August 2015 / Published online: 19 August 2015 Springer Science+Business Media New York 2015
Abstract The purpose of our study was to examine the potential effects of conventional 3D based radiotherapy on functional MRI activation areas following the treatment of glioblastoma multiforme. Seventeen patients with a histo-logically proven glioblastoma multiforme were enrolled in this study. A functional MRI examination was performed alongside the planning CT and conventional MRI prior to the delivery of conventional 3D based radiotherapy. All patients received 3D based postoperative radiotherapy (up to 60 Gy) combined with temozolomide. Follow-up fMRI examinations were performed after completion of the treatment in the 6th week and in 3 months time. Changes of the task related activation areas were registered and analyzed. The difference in changes of high dose and low dose areas of the brain were also registered and analyzed. The comparison of the pretreatment and 6th week control fMRI activation areas revealed signicant changes in motor activation and listening tasks in the case of brain areas which received a high dose (over 40 Gy). Based on the population level statistical parametric images (motor activation tasks) acquired at the 6th week control examination, a signicant increase of signal was registered in the precuneus region and in the globus pallidus region. When comparing the 6th week and 3rd month activation signals, no signicant changes were registered. Our results demonstrate the inuence of radiotherapy on functional
MRI signals within the human brain. Based on our ndings, functional activation transfers from high dose areas to low dose areas. In case of the motor activation tasks, activations of the secondary motor area were observed following radiotherapy.
Keywords fMRI Radiotherapy Signal changes
Background and purpose
Functional magnetic resonance imaging (fMRI) is an imaging...