Coenzyme Q10, Copper, Zinc, and Lipid Peroxidation Levels in Serum of Patients with Chronic Obstructive Pulmonary Disease

Biol Trace Elem Res (2011) 143:659667

DOI 10.1007/s12011-010-8897-5

Abdullah Cetin Tanrikulu & Abdurrahman Abakay & Osman Evliyaoglu & Yilmaz Palanci

Received: 13 August 2010 /Accepted: 3 November 2010 /

Published online: 16 November 2010# Springer Science+Business Media, LLC 2010

Abstract Severity of chronic obstructive pulmonary disease (COPD) exacerbation is associated with increased level of copper (Cu), zinc (Zn), and lipid peroxidation (malodialdehyde, MDA). The aim of this study was to investigate the levels of lipid peroxidation, Coenzyme Q10 (CoQ10), Zn, and Cu in the COPD exacerbations. Forty-five patients with COPD acute exacerbation and 45 healthy smokers as control group were used in the study. Forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) were lower in exacerbation group than in control. C- reactive protein levels, white blood cell count, and sedimentation rate were significantly (p<0.001) higher in patients than in control. CoQ10 level and Cu/Zn ratio was significantly (p<0.05) lower in patients than in control, although MDA, Cu, and Zn levels were significantly (p<0.05) higher in patients than in control. Negative correlations were found among MDA, Cu, Zn, FEV1, and FVC values in exacerbation and control subjects (p<0.05). In conclusion, we observed that oxidative stress in the exacerbation period of COPD patients was increased. The decrease in CoQ10 level and Cu/Zn ratio and elevation in Cu and Zn levels observed in the patients probably result from the defense response of organism and are mediated by inflammatory-like substances.

Keywords Chronic obstructive pulmonary disease . Exacerbation . Oxidative stress . Coenzyme Q10 . Copper . Zinc

A. C. Tanrikulu : A. Abakay

Department of Chest Disease, Medical Faculty, Dicle University, Diyarbakir, Turkey

O. Evliyaoglu

Department Biochemistry, Medical Faculty, Dicle University, Diyarbakir, Turkey

Y. Palanci

Department of Public Health, Medical Faculty, Dicle University, Diyarbakir, Turkey

A. C. Tanrikulu (*)

Department of Chest Diseases, School of Medicine, Dicle University, 21180 Diyarbakir, Turkey e-mail: [email protected]

Coenzyme Q10, Copper, Zinc, and Lipid

Peroxidation Levels in Serum of Patients with Chronic Obstructive Pulmonary Disease

660 Tanrikulu et al.

Abbreviations

BMI Body mass indexCOPD Chronic obstructive pulmonary diseaseCu CopperCoQ10 Coenzyme Q10CRP C-reactive proteinFEV1 Forced expiratory volume in 1 sFVC Forced vital capacityGOLD Global initiation for chronic obstructive lung disease LP Lipid peroxidationMDA MalonyldialdehydeZn ZincWBC White blood cell

Introduction

Chronic obstructive...