Abstract

Abstract

Background: Recently, human germinal center-associated lymphoma (HGAL) gene protein has been proposed as an adjunctive follicular marker to CD10 and BCL6.

Methods: Our aim was to evaluate immunoreactivity for HGAL in 82 cases of follicular lymphomas (FLs) - 67 nodal, 5 cutaneous and 10 transformed - which were all analysed histologically, by immunohistochemistry and PCR.

Results: Immunostaining for HGAL was more frequently positive (97.6%) than that for BCL6 (92.7%) and CD10 (90.2%) in FLs; the cases negative for bcl6 and/or for CD10 were all positive for HGAL, whereas the two cases negative for HGAL were positive with BCL6; no difference in HGAL immunostaining was found among different malignant subtypes or grades.

Conclusions: Therefore, HGAL can be used in the immunostaining of FLs as the most sensitive germinal center (GC)-marker; when applied alone, it would half the immunostaining costs, reserving the use of the other two markers only to HGAL-negative cases.

Details

Title
Comparison of germinal center markers CD10, BCL6 and human germinal center-associated lymphoma (HGAL) in follicular lymphomas
Author
Goteri, Gaia; Lucarini, Guendalina; Zizzi, Antonio; Costagliola, Antonello; Giantomassi, Federica; Stramazzotti, Daniela; Rubini, Corrado; Leoni, Pietro
Pages
97
Publication year
2011
Publication date
2011
Publisher
BioMed Central
e-ISSN
1746-1596
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/1746-1596-6-97
ProQuest document ID
902302539
Copyright
© 2011 Goteri et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.