Comparison of TPS, CEA, CYFRA21-1 and STNFR in diagnosis of lung cancer

Abstract

近年来,肿瘤标志物的研究不断取得新的进展。其中,组织多肽特异性抗原（TPS）、细胞角蛋白19片段（CYFRA21-1）和可溶性肿瘤坏死因子受体（STNFR）是近几年逐步应用于临床的新的肿瘤标志物。本研究旨在比较四种肿瘤标志物TPS、癌胚抗原（CEA）、CYFRA21-1和STNFR对肺癌的临床诊断价值。方法 用ELISA法对72例肺癌患者的血清TPS、CEA、CYFRA21-1和STNFR水平进行检测,并与54例肺部良性疾病患者及32例正常健康人比较。结果 四种肿瘤标志物在肺癌组的水平均明显高于良性疾病组（P < 0.005）和正常对照组（P < 0.001）。在对肺癌的诊断中,相对而言,STNFR的敏感性（81.9%）最高,CYFRA21-1的特异性（91.5%）最高,TPS的诊断符合率（83.5%）最高。结论 TPS、CYFRA21-1和STNFR均是用于肺癌诊断的较好的肿瘤标志物,优于传统标志物CEA,其中又以CYFRA21-1的综合临床应用价值最好。

Background and objective In recent years, new progress has been made in research of tumor markers. And namely tissue polypeptide specific antigen （TPS）, cytokeratin 19-fragments （CYFRA21-1） and soluble tumor necrosis factor receptor （STNFR） are new tumor markers that have been used in clinical application. The aim of this study is to determine and compare the diagnostic value of 4 kinds of tumor markers, TPS, carcinoembryonic antigen （CEA）, CYFRA21-1 and STNFR in patients with lung cancer. Methods The serum levels of TPS, CEA, CYFRA21-1 and STNFR were determined in 72 patients with lung cancer, 54 patients with pulmonary benign diseases and 32 healthy adults by enzyme-linked immunosorbent assay （ELISA）. Results The levels of the four tumor markers in lung cancer group were significantly higher than those in benign disease group （P < 0.005） and healthy control group （P < 0.001）. Among the four markers, STNFR had the highest sensitivity （81.9%）, CYFRA21-1 had the highest specificity （91.5%） and TPS had the highest accuracy （83.5%）. Conclusion TPS, CYFRA21-1 and STNFR can be used as very useful and sensitive tumor markers in the diagnosis of lung cancer, in which CYFRA21-1 may be the most useful tumor marker for clinical application.