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then this would require that the interactions between adjacent rod regions must be weakened in some way. If the filaments are templated then what features of the existing NM2 filament promote the nucleation of a nearby filament? Another intriguing question is how the NM2 filaments are drawn together to assemble into stacks. A combination of myosin motor activity and long-range forces that are pulling on the actin network are both likely to be required. The organization of the actin network itself, the cross-linkers that hold bundles together and the polarity of the filaments within a bundle must influence how such forces
are transmitted or dampened to permit maintenance of the filaments in register. Answers to these questions are likely to be revealed by future high-resolution live-cell imaging and the continued development of invitro assays that are able to faithfully recapitulate the formation of actomyosin networks14,15.
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The author declares no competing financial interests.
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