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Abstract
The present study was aimed to find out the protective effect of curcumin on hepatotoxicity resulting by commonly used antimalarial drug chloroquine (CQ). Albino rats were administered with CQ 200mg/Kg body wt. We observed statistically significant hepatotoxicity following CQ administration. We further observed a significant alterations in biochemical parameters such as total protein, aspartate transferase, alanine transaminase, superoxide dismutase and catalase on tested curcumin (300mg/Kg b.wt) against CQ-induced hepatotoxicity and also found encouraging results with histopathological examination of liver section when compared with normal group rats. It is evidenced that curcumin exerts significant protection against CQ induced toxicity due to its antioxidant activity. In conclusion, thus our study strongly suggest that curcumin along with CQ should be recommended for treating malaria, so as to avoid the toxic influences of the above mentioned drug.
Keywords: chloroquine, curcumin, hepatotoxicity, malaria
Asha S, Thirunavukkarasu P, Taju G (2019) Curcumin pretreated hepatoprotectivity against antimalarial drug chloroquine induced hepatotoxicity in albino rats. Eurasia J Biosci 13: 41-48.
© 2019 Asha et al.
This is an open-access article distributed under the terms of the Creative Commons Attribution License.
INTRODUCTION
Liver is a major organ, plays a central role in transforming and clearing the chemical agents (Romanelli etai. 2004) and also found to be susceptible to injury to some agents (Ahmed et al. 2006) when exposed to overdoses (Yakubu et al. 2018). Those chemicals that cause liver injury are termed as hepatotoxins. About 900 more drugs have been implicated in causing liver injury (Friedman et at. 2003). Most drugs enters the body via gastrointestinal tract and by absorption they reaches the liver through hepatic portal vein. Thus liver gets exposed to a highest concentration of toxicants (Reed 1994). Drugs encountered through other routes also reaches the liver through hepatic artery as well as portal vein (Kulkarni and Byczkowski 1994, Stacey et al. 1993).
Chloroquine can be used to cure malaria (Gasasira et al. 2003, Medilinks 2002, Noston and Brasseur 2002, Olajide et al. 2016, Olanrewaju and Johnson 2001, Schwartz 2003, Staedke et al. 2001, Wellem et al. 2001); auto immune disorders such as rheumatoid arthritis and systamic lupus erzytheromatosis (Augustijus 1993, Borba et al. 2004, Ippolito et al. 2018, Lee 2011, Romanelli et al. 2004); inflammation, extra intestinal amebiasis (or)...