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Brain Topogr (2015) 28:172183 DOI 10.1007/s10548-014-0379-1
ORIGINAL PAPER
Detection of Interictal Epileptiform Discharges Using Signal Envelope Distribution Modelling: Application to Epileptic and Non-Epileptic Intracranial Recordings
Radek Janca Petr Jezdik Roman Cmejla Martin Tomasek Gregory A. Worrell
Matt Stead Joost Wagenaar John G. R. Jefferys Pavel Krsek
Vladimir Komarek Premysl Jiruska Petr Marusic
Received: 19 August 2013 / Accepted: 27 May 2014 / Published online: 27 June 2014 Springer Science+Business Media New York 2014
Abstract Interictal epileptiform discharges (spikes, IEDs) are electrographic markers of epileptic tissue and their quantication is utilized in planning of surgical resection. Visual analysis of long-term multi-channel intracranial recordings is extremely laborious and prone to bias. Development of new and reliable techniques of automatic spike detection represents a crucial step towards increasing the information yield of intracranial recordings and to improve surgical outcome. In this study, we designed a novel and robust detection algorithm that adaptively models statistical distributions of signal envelopes and enables discrimination of signals containing
IEDs from signals with background activity. This detector demonstrates performance superior both to human readers and to an established detector. It is even capable of identifying low-amplitude IEDs which are often missed by experts and which may represent an important source of clinical information. Application of the detector to non-epileptic intracranial data from patients with intractable facial pain revealed the existence of sharp transients with waveforms reminiscent of interictal discharges that can represent biological sources of false positive detections. Identication of these transients enabled us to develop and propose secondary processing steps, which may exclude these transients, improving the detectors specicity and having important implications for future development of spike detectors in general.
Premysl Jiruska and Petr Marusic wish it to be known that, in their opinion, the last two authors should be regarded as joint Senior Authors and joint Corresponding Authors.
R. Janca P. Jezdik R. Cmejla
Department of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, Czech Republic
M. Tomasek P. Jiruska P. Marusic (&)
Department of Neurology, 2nd Faculty of Medicine, Motol University Hospital, Charles University in Prague, Prague, Czech Republice-mail: [email protected]
G. A. Worrell M. Stead
Mayo Systems Electrophysiology Laboratory, Mayo Clinic, Rochester, MN, USA
J. WagenaarDepartment of Neurology and Bioengineering, University of Pennsylvania, Philadelphia, PA,...