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ABSTRACT
Besides delivering drug to the body, a drug delivery system aims to improve patient compliance, patient acceptance. The dosage forms available for the delivery of topical agents include ointment, paste, lotion, moisturizing cream and powder. However creams are more preferable due to their properties. Present research work is attempted to develop moisturizing creams by using rice bran wax. Rice bran wax is the vegetable wax extracted from rice bran oil. The oil generally contains 2-6 % wax. However it is assumed that on an average it contains 3 % wax. Physicochemical tests such as globule size, evaluation of the intrinsic viscosity and homogeneity of cream products, have been traditionally used to provide reasonable evidence of consistent product performance. However, for the purposes of these studies, the final cream products were characterized by pH, particle size, spreadability, rheological measurement and in vitro occlusivity. All the results match with official specifications.
KEYWORDS: moisturizing cream, rice bran wax, occlusivity.
INTRODUCTION:
Waxes from both animals and plants are esters of high molecular weight monohydroxy alcohols and high molecular weight carboxylic acids. They are chemically different from fats and oils, from hydrocarbons or paraffin waxes, and from synthetic polyether waxes such as carbowax. Rice bran wax is obtained from natural sources (Oryza sativa, Family- Graminae) and is abundantly available1. Recent work indicated that Rice bran wax is mainly an ester of Lignoceric acid and Myricyl alcohol. It is hard non-tacky wax containing chiefly melissyl cerotate and melts at about 80-85° C. All these factors signify that Rice bran wax will prove to be better substitute of Carnauba wax and may save lot of foreign currency for our country if it replaces2,3. Therefore, this study is an attempt to probe the utility of rice bran wax in cosmetics products such as moisturizing cream.
MATERIALS:
The RBW was obtained as a gift sample from Space lab, Nasik in flakes form; stearic acid, lanoline, glycerin, sorbitol etc were obtained as a gift sample from Aquatic Remedies Mumbai.
METHODS:
Moisturizing cream formulations were developed from a prototype moisturizing cream formulation based on triethanolamine stearate. The final developed formulations were used for the preparation of all cream formulations developed and tested in these studies.
Formulation development:
In the preliminary stages of these...