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Prostaglandins (PG) produced by activated non-parenchymal liver cells regulate the function of parenchymal cells through six classes of G-protein-coupled receptors (-R): four receptor subtypes for PGE^sub 2^, EP1-R-EP4-R and one type each for PGD^sub 2^, DP-R, and PGF^sub 2α^, FP-R. The mechanisms by which prostaglandins modulate the hepatocyte responding phenotype are poorly characterized. We have studied the concentration and time effect of PGE^sub 2^, PGD^sub 2^...
