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http://crossmark.crossref.org/dialog/?doi=10.1007/s10552-017-0883-1&domain=pdf
Web End = Cancer Causes Control (2017) 28:497528
DOI 10.1007/s10552-017-0883-1
REVIEW ARTICLE
http://crossmark.crossref.org/dialog/?doi=10.1007/s10552-017-0883-1&domain=pdf
Web End = Does milk intake promote prostate cancer initiation orprogression viaeects oninsulin-like growth factors (IGFs)? Asystematic review andmeta-analysis
http://orcid.org/0000-0002-7966-0700
Web End = Abstract
Purpose To establish whether the association between milk intake and prostate cancer operates via the insulin-like growth factor (IGF) pathway (including IGF-I, IGF-II, IGFBP-1, IGFBP-2, and IGFBP-3).
Methods Systematic review, collating data from all relevant studies examining associations of milk with IGF, and those examining associations of IGF with prostate cancer risk and progression. Data were extracted from experimental and observational studies conducted in either humans or animals, and analyzed using meta-analysis where possible, with summary data presented otherwise.
Results One hundred and seventy-two studies met the inclusion criteria: 31 examining the milkIGF relationship; 132 examining the IGFprostate cancer relationship in humans; and 10 animal studies examining the IGFprostate cancer relationship. There was moderate evidence that
Sean Harrison and Rosie Lennon have contributed equally to this work, as have Richard M. Martin and Sarah J. Lewis.
Electronic supplementary material The online version of this article (doi:http://dx.doi.org/10.1007/s10552-017-0883-1
Web End =10.1007/s10552-017-0883-1 ) contains supplementary material, which is available to authorized users.
* Sarah J. Lewis [email protected]
1 School ofSocial andCommunity Medicine, University ofBristol, Bristol, UK
2 MRC Integrative Epidemiology Unit (IEU), University ofBristol, Bristol, UK
3 IGFs & Metabolic Endocrinology Group, School ofClinical Sciences atNorth Bristol, Southmead Hospital, BS105NBBristol, UK
4 Nuffield Department ofPopulation Health, University ofOxford, Oxford, UK
5 Cardi University, Cardi, UK
6 CLAHRC West, University ofBristol, Bristol, UK
7 International Agency forResearch onCancer, Lyon, France
8 School ofOral andDental Sciences,, University ofBristol,
Bristol, UK
9 Department ofPathology, University ofCambridge,
Cambridge, UK
10 National Institute forHealth Research Biomedical Research
Unit inNutrition, Diet andLifestyle, University Hospitals Bristol NHS Foundation Trust andtheUniversity ofBristol, BS28AEBristol, UK
SeanHarrison1,2http://orcid.org/0000-0002-7966-0700
Web End = RosieLennon1 JeHolly3 JulianP.T.Higgins1,2 MikeGardner1,4 ClairePerks3 TomGaunt1,2 VanessaTan1,2 CathBorwick1,5 PaulineEmmet1 MonaJereys1 KateNorthstone6 SabinaRinaldi7 StephenThomas8 SuzanneD.Turner9 AnnaPease1 VickyVilenchick1 RichardM.Martin1,2,10 SarahJ.Lewis1,2
Received: 10 May 2016 / Accepted: 10 March 2017 / Published online: 30 March 2017 The Author(s) 2017. This article is published with open access at Springerlink.com
circulating IGF-I and IGFBP-3 increase with milk (and dairy protein) intake (an estimated standardized eect size of 0.10 SD increase in IGF-I and 0.05 SD...