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Uneven pupillary dilatation was seen in a 28 year old junior doctor who was taking no other drugs and was being treated for a depressive disorder with sertraline. Although he usually had equal pupils, when he took 150 mg sertraline daily both of his pupils became dilated, the left more so by about a quarter. Treatment had started at 150 mg, and the effect had been noticed soon afterwards. It reversed within 48 hours of stopping treatment.
