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* Dutcher bodies are periodic acid-Schiff-positive intranuclear pseudoinclusions found in plasma cells in mucosa-- associated lymphoid tissue lymphoma, Waldenstrom macroglobulinemia, and myeloma. We describe the case of a 68-year-old woman with chronic synovitis containing multiple butcher bodies. The patient's workup for lymphoma was negative. Hematoxylin-eosin- and periodic acid-- Schiff-stained sections of 7 cases of marked chronic synovitis selected from the files spanning a 10-year period at Memorial Hospital of Rhode Island (Pawtucket, RI) were examined, and none showed butcher bodies. This case illustrates that butcher bodies may rarely occur in benign reactive conditions, such as chronic synovitis.
Dutcher bodies are periodic acid-Schiff (PAS)-positive eosinophilic intranuclear pseudoinclusions, a histologic feature strongly associated with low-grade malignant lymphomas, particularly lymphoplasmacytic lymphoma, mucosa-associated lymphoid tissue (MALT)-type lymphoma, or myeloma. butcher bodies are not typically associated with benign reactive conditions. We present the case of a 68-year-old woman with chronic synovitis showing multiple plasma cells containing PAS-positive butcher bodies and no evidence of a lymphoproliferative disorder.
REPORT OF A CASE
A 68-year-old woman with no significant past medical history presented with a soft tissue mass of her left foot. The mass was excised and consisted of a few irregularly shaped fragments of yellow-pink fibrofatty tissue measuring 5.5 X 4.0 x 1.0 cm. The patient's laboratory workup revealed a normal complete blood cell count.
MATERIALS AND METHODS
The entire specimen was routinely processed and stained with hematoxylin-eosin and PAS. Immunoperoxidase stains for (kappa) and (lambda) light chains were performed. Serum and urine electrophoretic studies were also performed. Patient nucleic acid was isolated from paraffin blocks and subjected to 35 cycles of polymerase chain reaction designed to detect immunoglobulin (Ig) H gene rearrangement, as previously described.1 Positive and negative controls were run in...