Abstract

N6-methyladenosine (m6A) is a chemical modification present in multiple RNA species, being most abundant in mRNAs. Studies on enzymes or factors that catalyze, recognize, and remove m6A have revealed its comprehensive roles in almost every aspect of mRNA metabolism, as well as in a variety of physiological processes. This review describes the current understanding of the m6A modification, particularly the functions of its writers, erasers, readers in RNA metabolism, with an emphasis on its role in regulating the isoform dosage of mRNAs.

Details

Title
Dynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism
Author
Yang, Ying 1 ; Hsu, Phillip J 2 ; Yu-Sheng, Chen 3 ; Yun-Gui, Yang 1   VIAFID ORCID Logo 

1  CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China; Institute of Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China 
2  Department of Chemistry and Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago, Chicago, IL, USA; Medical Scientist Training Program/Committee on Immunology, The University of Chicago, Chicago, IL, USA 
3  CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China 
Pages
616-624
Publication year
2018
Publication date
Jun 2018
Publisher
Nature Publishing Group
ISSN
10010602
e-ISSN
17487838
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41422-018-0040-8
ProQuest document ID
2052587130
Copyright
© 2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.