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The term "Bioinformatics" was first used by Paulien Hogeweg and Ben Hesper in the beginning of 1970s, defining it as ''the study of informatic processes in biotic systems''. Although they have proposed the definition as above in article in Dutch language that is not generally accessible [1] but various public sources trace the origin of the term to publications by Paulien Hogeweg and Ben Hesper that appeared in 1978 [2, 3]. Their main aim was to combine pattern analysis and dynamic modeling and apply them to the challenge of unraveling pattern generation and informatic processes in biotic systems at multiple scales but now a days meaning of the term has been superseded as denoting the development and use of computational methods for comparative analysis of genome data. The long term goals they set for bioinformatics in the 1970s, were termed by them as the "horse part" and the "elephant". The horse part is the "modeling morphogenesis, through the use of cell based models that incorporate some of the physical properties of cells [4]. Second but important part i.e. the elephant is "Constructive models of evolution", are generally being created from studies on the evolutionary consequences of non-linear physical mapping includes both genotype and phenotype mapping [5-8]. Metabolic networks [9-10], regulatory networks [11-14] and chromosome organization [15-17] are also providing useful information in the above model construction.