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Abstract
Treatments used for oral candidiasis such as ketoconazole bring many side effects such as allergies, nausea and in some cases causes irritation. Long-term use can also cause Candida albicans resistance problems to drugs. One of the traditional treatments that can inhibit the growth of Candida albicans is red ginger rhizome (Zingiber Officinale var Rubrum).
The objective of this research was to determine the benefits of ginger rhizome (Zingiber Officinale) as a bioactive compound in inhibiting the growth of Candida albicans and to determine the content of ginger rhizome (Zingiber Officinale) which plays a role in inhibiting the growth of Candida albicans. The method used in this research was literature study. The data was carried out by searching the PubMed, Science Direct and Google Scholar databases.
The results of the scoping review of most articles obtained supported the proven benefits of ginger rhizome (Zingiber Officinale) as a bioactive compound in inhibiting the growth of Candida albicans. The content of ginger rhizome (Zingiber Officinale) which played a role in inhibiting the growth of Candida albicans included essential oils, flavonoids, alkaloids, tannins, glycosides, saponins, steroids and triterpenoids. The conclusion of this scoping review is that ginger extract (Zingiber Officinale) can be used as a traditional treatment to inhibit the growth of Candida albicans.
Keywords: Ginger Rhizome (Zingiber Officinale), Candida albicans, Oral Candidiasis.
Introduction
The oral cavity is the entry and exit point for various microorganisms. In the oral cavity there are many normal flora. Normal flora under normal circumstances do not cause disease. However, if there is an immune disorder, the normal flora can turn into a pathogen. One of the normal flora that can be found in the oral cavity is Candida albicans.1 Candida albicans is a normal microflora of the oral cavity that often causes opportunistic infections in patients who have decreased body defenses caused by infection, by aging, diabetes and AIDS , iatrogenic factors. Candida albicans often colonizes the oral cavity by 30-60%.23
Infections caused by Candida albicans are oral candidiasis found on the dorsum of the tongue, buccal mucosa, labial mucosa and the _á_ area around the palate.3 The prevalence of oral candidiasis caused by Candida albicans in healthy humans without systemic disease is 20-75%. Meanwhile, oral candidiasis in humans has systemic...