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Abstract

Background: Gmelina arborea Roxb (Verbenaceae), also known as "Gambhari", is an important medicinal plant in the Ayurveda. There are no meticulous scientific reports on effect of the plant on inflammation and pain. Objective: To study the anti-inflammatory and anti-nociceptive properties of aqueous extracts (AE) and methanol extracts (ME) of G. arborea. Materials and Methods: The AE and ME of stembark of G. arborea was prepared by cold maceration and Soxhlet extraction technique respectively. Anti-inflammatory activity was determined in Wistar albino rats in a model of acute plantar inflammation induced by carrageenan. The anti-nociceptive activity was evaluated by using hot plate test and writhing test in Swiss albino mice. Significant differences between the experimental groups were assessed by analysis of variance. Results: AE and ME at dose of 500 mg/kg showed maximum inhibition in carrageenan induced inflammation up to 30.15 and 31.21% respectively. In hot plate test, the AE and ME showed the maximum response of 8.8 +- 0.97 (P < 0.01) and 8.2 +- 1.24 (P < 0.01) respectively at dose of 500 mg/kg when compared with control. AE showed maximum inhibition of writhing response (84.3%) as compared to ME (77.9%) in writhing test at a dose of 500 mg/kg. Conclusion: The findings suggested that G. arborea possess significant anti-inflammatory and anti-nociceptive activities.

Details

Title
Effect of Gmelina arborea Roxb in experimentally induced inflammation and nociception
Author
Kulkarni, Yogesh; Panjabi, Ritesh; Patel, Vishvas; Tawade, Aditi; Gokhale, Alok
Pages
152-157
Publication year
2013
Publication date
Jul-Sep 2013
Publisher
Elsevier Limited
ISSN
09759476
e-ISSN
09762809
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
1442195640
Copyright
Copyright Medknow Publications & Media Pvt Ltd Jul-Sep 2013