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Bulletin of Experimental Biology and Medicine, Vol. 152, No. 1, November, 2011
PHARMACOLOGY AND TOXICOLOGY
Effect of Ladasten on the Content of Cytokine Markers of Inammation and Behavior of Mice with Experimental Depression-Like Syndrome
A. V. Tallerova, L. P. Kovalenko, A. D. Durnev, and S. B. Seredenin
Translated from Byulleten Eksperimentalnoi Biologii i Meditsiny, Vol. 152, No. 7, pp. 65-67, July, 2011 Original article submitted December 27, 2010
The effects of ladasten and reference product imipramine (10 mg/kg) on the content of cytokines TNF-, IL-6, IL-10, IL-1, IL-2, IL-4, IL-5, IL-17, IFN-, and GM-CSF and behavior of male C57Bl/6 mice were studied on the model of a depression-like state induced by a single intraperitoneal injection of bacterial LPS in a dose of 100 g/kg. Ladasten was injected 5 times in doses of 30 and 50 mg/kg. LPS was administered 1 h after the last injection of the test agents. Behavioral disturbances and signicant increase in the concentration of TNF- and IL-6 in blood plasma were observed 2 h after LPS treatment. Ladasten was more potent than imipramine in decreasing the content of proinammatory cytokines TNF- and IL-6 and preventing the development of behavioral disturbances in mice. Antiasthenic drug ladasten was shown to decrease the elevated level of proinammatory cytokines TNF- and IL-6 after LPS treatment. Further studies should be performed to develop new indications for the use of ladasten in adjuvant therapy of depression.
Key Words: ladasten; inammation; depression-like syndrome; cytokines; behavior
Inammatory changes in the brain serve as one of the major etiopathogenetic factors for depression [6,9]. The severity of inammatory reactions and content of circulating proinammatory cytokines were shown to increase in depressive patients [4,7,10]. A positive correlation was found between the concentration of proinammatory cytokines and risk for the development of depressions, degree of depressive symptoms, cognitive disorders, and low efciency of standard antidepressants [2,5].
Previous studies showed that psychotropic drugs have the immunomodulatory properties [2]. Adminis-
tration of some antidepressants is followed by a decrease in the content of proinammatory cytokines TNF-, IL-2, and IL-6 and increase in the activity of anti-inammatory cytokines [8]. Therefore, it is necessary to perform an experimental study of proinamma-tory cytokines on the model of depression. Variations in the concentration of these compounds should...