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Web End = Brain Topogr (2015) 28:879894 DOI 10.1007/s10548-015-0430-x
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Web End = Effects of Hydrogen Sulde on Modulation of ThetaGamma Coupling in Hippocampus in Vascular Dementia Rats
Xiaxia Xu1 Chunhua Liu2 Zhanyong Li1 Tao Zhang1
Received: 12 July 2014 / Accepted: 4 March 2015 / Published online: 14 March 2015 Springer Science+Business Media New York 2015
Abstract Our previous study showed that hydrogen sulde (H2S) could alleviate the cognitive decits in vascular dementia (VD) rats associated with the improvement of synaptic plasticity. Neural oscillations are reported to interact with each other through either identical-frequency or cross-frequency coupling. This study examined whether impaired neural couplings could be alleviated by H2S in the hippocampal CA3CA1 of VD rats and explored its possible mechanism. A VD rat model was established by two-vessel occlusion. Sodium hydrosulde (NaHS), a kind of H2S donor, was administered intraperitoneally (5.6 mg/kg/day) for 3 weeks. Local eld potentials were simultaneously collected in the hippocampal CA3 and CA1. The effects of NaHS on the modulation of thetagamma coupling were evaluated by using the measurements of both phasephase coupling and phaseamplitude coupling, while several other approaches including behavior, electrophysiology, western blot, immunouorescence staining were also employed. The results showed that NaHS signicantly prevented spatial learning and memory impairments (p \ 0.01).
NaHS considerably alleviated the impairment of neural coupling in VD rats in an identical-frequency rhythm and
between cross-frequency bands. Moreover, the expression of cystathionine-b-synthase (CBS) was markedly attenuated in VD rats. NaHS elevated the expression of CBS to maintain the intrinsic balance of H2S. Interestingly, it was observed that NaHS increased the protein expression of N-methyl-D-aspartic acid receptor 2A (NMDAR2A) in VD rats. In conclusion, the data suggest that NaHS played the neuroprotective role partly via modulating the expression of NMDAR2A in order to alleviate the impairments of neural couplings in VD rats.
Keywords Theta Gamma Vascular dementia
Hydrogen sulde Identical frequency coupling Cross
frequency coupling
AbbreviationsCFC Cross frequency couplingCMI Conditional mutual information fEPSP Field excitatory postsynaptic potential H2S Hydrogen sulde
NaHS Sodium hydrosuldeLFP Local eld potentialLTP Long term...