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Abstract
Twenty-seven dogs with angioedema, were enrolled in this clinical study. The cases were randomly assigned to the treatment group (n=15) and untreated placebo control group (n=12). It was concluded that mepyramine maléate has the potential to be helpful for dogs with angioedema.
Key Words: dog, angioedema, treatment, mepyramine maléate, clinical study
Introduction
Angioedema, a classic type 1 hypersensitivity disorder (Bircher 1999), is an abrupt asymmetrical swelling of tissue (Khalaf et al. 2008) and occurs as a result of increased permeability of subcutaneous or submucosal capillaries and post capillary venules. The latter local permeability increase causes localized plasma extravasation against histamine and bradykinin (Bas et al. 2006). Although the cause of angioedema is often undiagnosed, the suspected causes may include drugs, vaccines, infections, food intolerance, and insect bites (Bircher 1999).
Traditional Hi-type antihistamines have been suggested as symptomatic and alternative therapeutic agents for angioedema treatment alone (Black and Greaves 2002) or in combination with prednisolone (Borazan et al. 2003).
The purpose of this controlled clinical study was to investigate the clinical efficacy of mepyramine maleate in treating angioedema in dogs.
Materials and Methods
A total of 27 dogs with history of acute onset angioedema were enrolled in this study. Breeds investigated included: 7 Golden Retriever, 5 German Shepherd dog, 4 Belgian Shepherd dog, 3 Turkish Shepherd dog, 2 Boxer, 1 Doberman Pinscher and 5 cross-breed. Their age ranged between 3 months to 4 years. They included 16 puppies, five females and six males.
Historical data, aetiologies, clinical features, course of the angioedema, treatment and outcome by monitorization were...