Abstract

Methamphetamine (METH) is an addictive drug causes toxicity and degeneration in the brain. Several evidence have demonstrated that METH toxicity results oxidative stress that regulate an intracellular signaling cascade that leads to cell death. In this paper we studied the effect of METH on calcium levels because of its great importance on human health. Calcium, is a messenger of extracellular signals in a great variety of cells; it regulates several neuronal functions, such as neurotransmitter synthesis and release, neuronal excitability, phosphorylation. Calcium is also involved in long-term processes, like memory. As well, we highlighted sodium levels to find out the main course in nerve function and to keep body fluids in balance.

The study was conducted on eighty people divided into three groups, thirty non addicted men as a control group(G1), taking into account and excluding, cigarette smoking, age, social and cultural conditions, and chronic diseases, also thirty people addicted to methamphetamine(G2), and twenty people addicted to methamphetamine and other narcotic substances (mix)(G3), whose ages ranged between (15-45) years and the period of methamphetamine abuse ranged between (1-7) years.

Calcium levels were highly significant in addicts group (P < 0.05), as compared to non addicts group. as well, when dividing by age, Calcium level were higher in METH and MIX addicts group (A2) as compared to addicts group (A1) and (A3) (P >0.05). Also, Calcium level were higher in METH and MIX addicts group (D3) as compared to addicts group (D1) and (D2) (P >0.05). We have noticed Increased duration of abuse Increases calcium levels. In addition to, Sodium levels were highly significant in addicts group (P < 0.05), as compared to non addicts group. During the study, it was found that age had an effect on sodium levels, Sodium level were higher in METH addicts group (A1) as compared to addicts group (A2) and (A3) (P> 0.05). While, Sodium level were higher in MIX addicts group (A2) as compared to addicts group (A1) and (A3) (P> 0.05). As well, Sodium level were higher in METH and MIX addicts group (D2) as compared to addicts group (D1) and (D3) (P> 0.05). Indeed, the difference in the duration of the abuse affects the sodium levels.

Details

Title
Elevated of Calcium and Sodium Levels as a Result of Methamphetamine Addiction, Causesand Consequence
Author
Abood, Mushtaq T 1 ; Almashhedy, Lamia A 1 

 Ministry of interior/Federal security agency/ Border guard force command, Baghdad, Iraq 
Publication year
2020
Publication date
Nov 2020
Publisher
IOP Publishing
ISSN
17578981
e-ISSN
1757899X
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2562789643
Copyright
© 2020. This work is published under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.