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Inducers of microsomal enzymes stimulate the metabolism of drugs that leads to the reduced desired pharmacological response time. So that due to presence of an enzyme inducer the duration of action of second drug will be reduced. Treatment of rats with phenobarbitone (PB) decreases the onset of time and increases the duration of action of sleeping time in the dose of 45mg/ kg of body weight by i.p route. But in the combination of pentobarbital followed by the phenobarbitone in the dose of 50mg/kg of body weight by i.p route produces opposite effect is increases the onset of time and decreases the duration of action of sleeping time due to the microsomal induction of pentobarbitone by the phenobarbitone.
INTRODUCTION
The drugs which induce hepatic microsomal oxidative enzyme system enhance the metabolism of other drugs. As a result in the presence of an enzyme induces the duration of action of second drug will be reduced. This has significant clinical relevance because when more than one drug is administered at a time one drug may modify the action of another drug through the microsomal enzyme inducing properly.
The common drugs which induce hepatic microsomal enzyme system are phenobarbitone and meprobamate. Co-administration of any drug with either of these drugs may affect the disposition of the second drug and therefore the desired pharmacological effect.
Pentobarbital
A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration (Goyal, 2008). Pentobarbital, a barbiturate, is used for the treatment of short term insomnia. It belongs to a group of medicines called central nervous system (CNS)...