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J Neurooncol (2014) 119:343351 DOI 10.1007/s11060-014-1484-4
CLINICAL STUDY
Evaluation of osteopontin as a potential biomarker for central nervous system embryonal tumors
Yi-Peng Han Chen-Kai Ma Shen-Qi Wang
Atsushi Enomoto Yang Zhao Masahide Takahashi
Jie Ma
Received: 26 November 2013 / Accepted: 19 May 2014 / Published online: 31 May 2014 Springer Science+Business Media New York 2014
Abstract Osteopontin (OPN) is a protein linked to tumor growth, progression and metastasis of cancers. However, its role in the progression of central nervous system (CNS) embryonal tumors such as atypical teratoid/rhabdoid tumor (AT/RT), medulloblastoma (MB) and primitive neuroepithelial tumors (PNET) remains elusive. In this study, we investigated the value of OPN staining in differential diagnosis of AT/RT from MB and PNET, and assessed the correlation between OPN expression and patients prognosis. This retrospective study was conducted on tissue sections obtained from children cases with CNS embryonal tumors treated in Xinhua Hospital Afliated to Shanghai Jiaotong University School of Medicine from 2006 to 2012 by immunohistochemistry (IHC). 49 cases were collected(11 AT/RTs, 25 MBs, and 13 PNETs), with a median follow-up time of 28.9 months. OPN expression in AT/RT was signicantly higher than MB and PNET with the positive rates of 100, 32, and 23 %, respectively (P \ 0.01). The specicity and sensitivity of OPN staining in diagnosing AT/RT are 97.4 and 90.9 %, respectively, as judged by strong OPN IHC staining level (???). Patients
who had positive OPN staining have increased risks of poorer median overall survival (hazard risk 5.54, 95 % CI1.8716.38) and tumor progression (hazard risk 14.47, 95 % CI 4.4746.85). OPN is a valuable biomarker to aid in the differential diagnosis between AT/RT and MB/PNET. Moreover, OPN is a potential novel prognostic marker for CNS embryonal tumors.
Keywords Central nervous system (CNS) Osteopontin
(OPN) Atypical teratoid/rhabdoid tumor (AT/RT)
Medulloblastoma (MB) Primitive neuroepithelial tumors
(PNET) Progression
Introduction
Embryonal tumors of the central nervous system (CNS) are a group of highly malignant tumors, which usually affect young children. According to the WHO classication of tumors of the CNS published in 2007, these tumors are subdivided into medulloblastoma (MB), the primitive neuroepithelial tumors (PNETs) and atypical teratoid/ rhabdoid tumors (AT/RT) [1]. Although these tumors belong to the same embryonal group due to their similar macro histology, there...