Content area
Full Text
http://crossmark.crossref.org/dialog/?doi=10.1007/s10067-016-3275-0&domain=pdf
Web End = Clin Rheumatol (2016) 35:27572763
DOI 10.1007/s10067-016-3275-0
http://crossmark.crossref.org/dialog/?doi=10.1007/s10067-016-3275-0&domain=pdf
Web End = ORIGINAL ARTICLE
Evaluation of subclinical inflammation in familial Mediterranean fever patients: relations with mutation types and attack status:a retrospective study
Fatih Mehmet Kelesoglu1 & Erhan Aygun1 & Nazli Kubra Okumus1 & Ayenur Ersoy1 &
Edanur Karapnar1 & Nesibe Saglam1 & Nur Gokce Aydn1 & Beyza Betul Senay1 &
Sumeyye Gonultas1 & Elif Sarisik1 & Melike Zeynep Can1 & Sirin Atay1 &
Dilruba Basbug1 & Feyza Kubra Tiryaki1 & Sena Ozer1 & Rana Berru Durmus1 &
Fatih Orem1 & Tugrul Atay2 & Ahmet Acar3,4 & Yasin Yilmaz5 & Seyma Kaya1 &
Aylin Ciftkaya1 & Zeynep Sarac1 & Cagri Can Makar1 & Basak Saracoglu1 &
Gafur Dogdu6 & Rukiye Eker Omeroglu1
Received: 23 March 2016 /Revised: 11 April 2016 /Accepted: 13 April 2016 /Published online: 23 April 2016 # International League of Associations for Rheumatology (ILAR) 2016
Abstract Familial Mediterranean fever (FMF) is an autosomal recessive autoinflammatory disease of childhood and
adulthood. Development of systemic amyloidosis and frequent attack influence quality of life and survival. There is
* Fatih Mehmet Kelesoglu [email protected]
Erhan Aygun [email protected]
Nazli Kubra Okumus [email protected]
Ayenur Ersoy [email protected]
Edanur Karapnar [email protected]
Nesibe Saglam [email protected]
Nur Gokce Aydn [email protected]
Beyza Betul Senay [email protected]
Sumeyye Gonultas [email protected]
Elif Sarisik [email protected]
Melike Zeynep Can [email protected]
Sirin Atay [email protected]
Dilruba Basbug [email protected]
Feyza Kubra Tiryaki [email protected]
Sena Ozer [email protected]
Rana Berru Durmus [email protected]
Fatih Orem [email protected]
Tugrul Atay [email protected]
Ahmet Acar [email protected]
Seyma Kaya [email protected]
Aylin Ciftkaya [email protected]
Zeynep Sarac [email protected]
Cagri Can Makar [email protected]
Basak Saracoglu [email protected]
2758 Clin Rheumatol (2016) 35:27572763
sporadic evidence indicating subclinical inflammation in patients with FMF. We aimed to assess subclinical inflammation using neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and C-reactive protein (CRP) in pediatric patients with FMF in the attack-free period. In this retrospective study, we reviewed the files of all FMF patients in our pediatric rheumatology outpatient clinic in a tertiary center and enrolled those with sufficient clinical and laboratory data. We also enrolled 73 controls. We grouped the patients according to being in attack period or attack-free period. We compared CRP, NLR, PLR, and WBC (white blood cell) levels between different mutations and polymorphisms. We also compared patients in the...